First it is very useful and important to read the following study:
Bicarbonate Increases Tumor pH and Inhibits Spontaneous Metastases
The external pH of solid tumors is acidic as a consequence of increased metabolism of glucose and poor perfusion. Acid pH has been shown to stimulate tumor cell invasion and metastasis in vitro and in cells before tail vein injection in vivo. The present study investigates whether inhibition of this tumor acidity will reduce the incidence of in vivo metastases. Here, we show that oral NaHCO3 selectively increased the pH of tumors and reduced the formation of spontaneous metastases in mouse models of metastatic breast cancer. This treatment regimen was shown to significantly increase the extracellular pH, but not the intracellular pH, of tumors by 31P magnetic resonance spectroscopy and the export of acid from growing tumors by fluorescence microscopy of tumors grown in window chambers. NaHCO3 therapy also reduced the rate of lymph node involvement, yet did not affect the levels of circulating tumor cells, suggesting that reduced organ metastases were not due to increased intravasation. In contrast, NaHCO3 therapy significantly reduced the formation of hepatic metastases following intrasplenic injection, suggesting that it did inhibit extravasation and colonization. In tail vein injections of alternative cancer models, bicarbonate had mixed results, inhibiting the formation of metastases from PC3M prostate cancer cells, but not those of B16 melanoma. Although the mechanism of this therapy is not known with certainty, low pH was shown to increase the release of active cathepsin B, an important matrix remodeling protease.
Natural News Network, Wednesday, May 16, 2012 by: Mark Sircus., AC, OMD
(NaturalNews) The cancer industry is closing in on baking soda and beginning to do research in earnest about sodium bicarbonate and how it is a primary tool in the treatment of fungus. Cancer is a fungus, can be caused by a fungus, or is accompanied by late-stage fungal infections, and now the Mayo Clinic confirms this. They are not the first to say so though. Many, even from the official world of orthodox oncology, recognize the similarities of cancer and fungal infections, the decay that ties these two together in a dance that all too often ends in miserable death.
The Mayo Clinic is saying that a fungal infection of the gastrointestinal tract mimics cancer and inflammatory bowel disease. The invasive fungus, Basidiobolus ranarum, is typically found in the soil, decaying organic matterand the gastrointestinal tracts of fish, reptiles, amphibians, and bats.
Patients with this fungal infection had non-specific symptoms such as abdominal pain or a mass that could be felt on examination. Before a conclusive diagnosis of the fungal infection was made, most patients were thought to have abdominal cancer, inflammatory bowel disease or diverticulitis. Surgical resection of the area of involvement and prolonged antifungal therapy successfully treated most patients.
Interestingly, a few years ago researchers at Johns Hopkins were surprised that the drug itraconazole, commonly used to treat toenail fungus, can also block angiogenesis, the growth of new blood vessels commonly seen in cancers. Tumor angiogenesis is the proliferation of a network of blood vessels that penetrates into cancerous growths, supplying nutrients and oxygen and removing waste products. Cancer researchers studying the conditions necessary for cancer metastasis have discovered that angiogenesis is one of the critical events required for metasteses to occur. In mice induced to have excess blood vessel growth, treatment with itraconazole reduced blood vessel growth by 67% compared to placebo. “We were surprised, to say the least, that itraconazole popped up as a potential blocker of angiogenesis,” says Dr. Jun O. Liu, professor of pharmacology. “We couldn’t have predicted that an antifungal drug would have such a role.” Itraconazole was found to reduce the numbers of circulating cancer cells, prevent the worsening of prostate cancers, and delay the need for chemotherapy. However, it has serious side effects when given in the necessary high dosages that include hypertension, low potassium levels and fluid retention. These side effects require treatment with other medications. Effects of high doses of itraconazole could lead to heart failure.
For two decades John Hopkins has recognized the increasing frequency of severe fungal infections in patients with neoplastic diseases. Most fungal infections are caused by the commonly recognized opportunistic fungi Candida spp and Aspergillus spp, and the pathogenic fungi Cryptococcus neoformans, Histoplasma capsulatum, Coccidiodes immitis, and less often by Blastomyces dermatidis. However, recently newer pathogens such as Pheohyphomycetes, Hyalohyphomycetes, Zygomycetes and other fungi of emerging importance such as Torulopsis glabrata, Trichosporon beigelii, Malassezia spp, Saccharomyces spp, Hansenula spp, Rhodotorula spp, and Geotrichum candidum have appeared as significant causes of infection in this patient population.